Something old, something new.

“Something You Do with Your Body”: The Experience and Meaning of Physical Activity from the Perspective of Transnational Youth

Background. The transnational young people’s physical activity participation could intermingle with their ingrained dispositions acquired from their pre-migrating periods, experiences of transnational mobility, new cultural learning, and other migration processes.  Objectives. The current study aimed to investigate transnational youth’s physical activity experience using photo-elicitation inte...

Something Old and Something New in One-dimensional Models of Strongly Correlated Electrons

Something old, something new: biomarkers in rheumatoid arthritis.

Re-tooling critical care to become a better intensivist: something old and something new

Developments in recent years have placed powerful new tools of diagnosis, therapy, and communication at the disposal of medicine in general, and of critical care in particular. The art of healing requires not only technical proficiency, but also personal connection, multidisciplinary teamwork, and commitment to the venerable traditions of our profession. The latter often seem to be under assaul...

Peroxisome biogenesis: something old, something new, something borrowed.

Eukaryotic cells are characterized by their varied complement of organelles. One set of membrane-bound, usually spherical compartments are commonly grouped together under the term peroxisomes. Peroxisomes function in regulating the synthesis and availability of many diverse lipids by harnessing the power of oxidative reactions and contribute to a number of metabolic processes essential for cell...

Challenges and Opportunities for Quantitative Clinical Pharmacology in Cancer Immunotherapy: Something Old, Something New, Something Borrowed, and Something Blue

Cancer immunotherapy (CIT) initiates or enhances the host immune response against cancer. Following decades of development, patients with previously few therapeutic options may now benefit from CIT. Although the quantitative clinical pharmacology (qCP) of previous classes of anticancer drugs has matured during this time, application to CIT may not be straightforward since CIT acts via the immun...